SLC22A4 Chromosome 5
Solute carrier family 22 member 4
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What This Gene Does
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Solute carrier family 22
Locus Type
gene with protein product
Location
5q31.1
Ensembl
ENSG00000197208
Associated Conditions (1)
Rheumatoid arthritis
Key Variants
All Variants (3)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS762018264 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS781510670 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS3792876 | Health Risk | risk factor | Rheumatoid arthritis, Rheumatoid arthritis |