SIRT6 Chromosome 19
Sirtuin 6
Upload your DNA to see your personal genotypes for variants in SIRT6.
What This Gene Does
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Gene Info
Gene Group
Sirtuins
Locus Type
gene with protein product
Location
19p13.3
Ensembl
ENSG00000077463
Associated Conditions (1)
Premature ovarian failure
Key Variants
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS771714154 | Health Risk | Likely pathogenic | Premature ovarian failure, Premature ovarian failure |