SIPA1 Chromosome 11
Signal-induced proliferation-associated 1
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What This Gene Does
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"PDZ domain containing|MicroRNA protein coding host genes"
Locus Type
gene with protein product
Location
11q13.1
Ensembl
ENSG00000213445
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS150937195 | Health Risk | Conflicting classifications of pathogenicity | — |