SIN3A Chromosome 15

SIN3 transcription regulator family member A

97 variants 97 Health Risk

Upload your DNA to see your personal genotypes for variants in SIN3A.

What This Gene Does

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

Gene Info

Gene Group

"EMSY complex|SIN3 histone deacetylase complex subunits"

Locus Type

gene with protein product

Location

15q24.2

Ensembl

ENSG00000169375

Associated Conditions (9)

Inborn genetic diseases

SIN3A-related disorder

See cases

SIN3A-related intellectual disability syndrome due to a point mutation

Uterine corpus endometrial carcinoma

Neurodevelopmental disorder

SIN3A-related intellectual disability syndrome

Intellectual disability

Gastric cancer

Key Variants

RS142724257

Conflicting classifications of pathogenicity

Health Risk

RS200501190

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

RS201113909

Conflicting classifications of pathogenicity

Inborn genetic diseases, SIN3A-related disorder, Inborn genetic diseases

Health Risk

RS201414754

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

RS201853552

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

RS2141396034

Conflicting classifications of pathogenicity

See cases, See cases

Health Risk

RS2542982542

Conflicting classifications of pathogenicity

Health Risk

RS367989965

Conflicting classifications of pathogenicity

Health Risk

RS371395364

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

RS372433846

Conflicting classifications of pathogenicity

Health Risk

RS372626992

Conflicting classifications of pathogenicity

Health Risk

RS377177543

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

All Variants (97)

RSID	Category	Clinical Significance	Conditions
RS142724257	Health Risk	Conflicting classifications of pathogenicity	—
RS200501190	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS201113909	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, SIN3A-related disorder, Inborn genetic diseases
RS201414754	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS201853552	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS2141396034	Health Risk	Conflicting classifications of pathogenicity	See cases, See cases
RS2542982542	Health Risk	Conflicting classifications of pathogenicity	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS367989965	Health Risk	Conflicting classifications of pathogenicity	SIN3A-related intellectual disability syndrome due to a point mutation, Inborn genetic diseases, SIN3A-related intellectual disability syndrome due to a point mutation
RS371395364	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS372433846	Health Risk	Conflicting classifications of pathogenicity	—
RS372626992	Health Risk	Conflicting classifications of pathogenicity	—
RS377177543	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS532044975	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS551685122	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS757810589	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS759972441	Health Risk	Conflicting classifications of pathogenicity	SIN3A-related intellectual disability syndrome due to a point mutation, Uterine corpus endometrial carcinoma, SIN3A-related intellectual disability syndrome due to a point mutation
RS760515812	Health Risk	Conflicting classifications of pathogenicity	—
RS767080621	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS944211695	Health Risk	Conflicting classifications of pathogenicity	—
RS995271451	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS1347764887	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS1555444022	Health Risk	Likely pathogenic	—
RS1555444809	Health Risk	Likely pathogenic	—
RS1595897117	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS1595904430	Health Risk	Likely pathogenic	—
RS2072844502	Health Risk	Likely pathogenic	—
RS2072974210	Health Risk	Likely pathogenic	—
RS2073273656	Health Risk	Likely pathogenic	—
RS2073302769	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2073382517	Health Risk	Likely pathogenic	—
RS2141368718	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2141396556	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2141415824	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2141486160	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2141487276	Health Risk	Likely pathogenic	Neurodevelopmental disorder, Neurodevelopmental disorder
RS2542611773	Health Risk	Likely pathogenic	—
RS2542638801	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2542701033	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2542708046	Health Risk	Likely pathogenic	—
RS2542751349	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2542752176	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2542981693	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2543061981	Health Risk	Likely pathogenic	SIN3A-related disorder, SIN3A-related disorder
RS2543075783	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2543076887	Health Risk	Likely pathogenic	SIN3A-related intellectual disability syndrome, SIN3A-related intellectual disability syndrome
RS1064796919	Health Risk	Pathogenic	—
RS1135401768	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS1555441161	Health Risk	Pathogenic	—
RS1555443600	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS1555443627	Health Risk	Pathogenic	—

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