SIGLEC1 Chromosome 20
Sialic acid binding Ig like lectin 1
Upload your DNA to see your personal genotypes for variants in SIGLEC1.
What This Gene Does
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection. [provided by RefSeq, Dec 2021]
Gene Info
Gene Group
"CD molecules|V-set domain containing|C2-set domain containing|I-set domain containing|Sialic acid binding Ig like lectins"
Locus Type
gene with protein product
Location
20p13
Ensembl
ENSG00000088827
Key Variants
All Variants (4)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS146938047 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS147277415 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS200539652 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS759278527 | Health Risk | Conflicting classifications of pathogenicity | — |