SGPL1 Chromosome 10
Sphingosine-1-phosphate lyase 1
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What This Gene Does
Enables sphinganine-1-phosphate aldolase activity. Involved in apoptotic signaling pathway; fatty acid metabolic process; and sphingolipid metabolic process. Located in endoplasmic reticulum. Implicated in nephrotic syndrome type 14. [provided by Alliance of Genome Resources, Jul 2025]
Associated Conditions (2)
Nephrotic syndrome 14
Nephrotic syndrome
Key Variants
RS188194665
Conflicting classifications of pathogenicity
Health Risk
RS761684028
Conflicting classifications of pathogenicity
Nephrotic syndrome 14, Nephrotic syndrome 14
Health Risk
RS1564622701
Likely pathogenic
Nephrotic syndrome 14, Nephrotic syndrome 14
Health Risk
RS2492798769
Likely pathogenic
Health Risk
RS2492813518
Likely pathogenic
Nephrotic syndrome 14, Nephrotic syndrome 14
Health Risk
RS370799576
Likely pathogenic
Health Risk
RS779485098
Likely pathogenic
Health Risk
RS1131692235
Pathogenic
Nephrotic syndrome 14, Nephrotic syndrome 14
Health Risk
RS1131692252
Pathogenic
Nephrotic syndrome 14, Nephrotic syndrome 14
Health Risk
RS1131692253
Pathogenic
Nephrotic syndrome 14, Nephrotic syndrome 14
Health Risk
RS1131692254
Pathogenic
Nephrotic syndrome 14, Nephrotic syndrome 14
Health Risk
RS1131692255
Pathogenic
Nephrotic syndrome 14, Nephrotic syndrome 14
Health Risk
All Variants (25)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS188194665 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS761684028 | Health Risk | Conflicting classifications of pathogenicity | Nephrotic syndrome 14, Nephrotic syndrome 14 |
| RS1564622701 | Health Risk | Likely pathogenic | Nephrotic syndrome 14, Nephrotic syndrome 14 |
| RS2492798769 | Health Risk | Likely pathogenic | — |
| RS2492813518 | Health Risk | Likely pathogenic | Nephrotic syndrome 14, Nephrotic syndrome 14 |
| RS370799576 | Health Risk | Likely pathogenic | — |
| RS779485098 | Health Risk | Likely pathogenic | — |
| RS1131692235 | Health Risk | Pathogenic | Nephrotic syndrome 14, Nephrotic syndrome 14 |
| RS1131692252 | Health Risk | Pathogenic | Nephrotic syndrome 14, Nephrotic syndrome 14 |
| RS1131692253 | Health Risk | Pathogenic | Nephrotic syndrome 14, Nephrotic syndrome 14 |
| RS1131692254 | Health Risk | Pathogenic | Nephrotic syndrome 14, Nephrotic syndrome 14 |
| RS1131692255 | Health Risk | Pathogenic | Nephrotic syndrome 14, Nephrotic syndrome 14 |
| RS1196497635 | Health Risk | Pathogenic | — |
| RS2492759374 | Health Risk | Pathogenic | — |
| RS2492765537 | Health Risk | Pathogenic | Nephrotic syndrome 14, Nephrotic syndrome 14 |
| RS2492804665 | Health Risk | Pathogenic | — |
| RS2492804842 | Health Risk | Pathogenic | Nephrotic syndrome 14, Nephrotic syndrome 14 |
| RS370111307 | Health Risk | Pathogenic | — |
| RS374024951 | Health Risk | Pathogenic | Nephrotic syndrome 14, Nephrotic syndrome 14 |
| RS746887949 | Health Risk | Pathogenic | Nephrotic syndrome 14, Nephrotic syndrome 14 |
| RS757042460 | Health Risk | Pathogenic | — |
| RS769259446 | Health Risk | Pathogenic | Nephrotic syndrome 14, Nephrotic syndrome, Nephrotic syndrome 14 |
| RS779596408 | Health Risk | Pathogenic | — |
| RS867880706 | Health Risk | Pathogenic | — |
| RS1131692256 | Health Risk | Pathogenic/Likely pathogenic | Nephrotic syndrome 14, Nephrotic syndrome, Nephrotic syndrome 14 |