SFRP2 Chromosome 4
Secreted frizzled related protein 2
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What This Gene Does
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Secreted frizzled-related proteins
Locus Type
gene with protein product
Location
4q31.3
Ensembl
ENSG00000145423
Associated Conditions (1)
Anophthalmia-microphthalmia syndrome
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS770485715 | Health Risk | Conflicting classifications of pathogenicity | Anophthalmia-microphthalmia syndrome, Anophthalmia-microphthalmia syndrome |