SEMA3B Chromosome 3
Semaphorin 3B
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What This Gene Does
The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Info
Gene Group
"Immunoglobulin like domain containing|Semaphorins|MicroRNA protein coding host genes"
Locus Type
gene with protein product
Location
3p21.31
Ensembl
ENSG00000012171
Associated Conditions (1)
SEMA3B-related disorder
Key Variants
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS921870045 | Health Risk | Conflicting classifications of pathogenicity | SEMA3B-related disorder, SEMA3B-related disorder |