SCN10A Chromosome 3
Sodium voltage-gated channel alpha subunit 10
Upload your DNA to see your personal genotypes for variants in SCN10A.
What This Gene Does
The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Info
Gene Group
Sodium voltage-gated channel alpha subunits
Locus Type
gene with protein product
Location
3p22.2
Ensembl
ENSG00000185313
Associated Conditions (9)
Brugada syndrome
Cardiovascular phenotype
Episodic pain syndrome
familial
2
Brugada syndrome 1
SCN10A-related disorder
See cases
Hereditary sodium channelopathy-related small fibers neuropathy
Key Variants
RS112774699
Conflicting classifications of pathogenicity
Brugada syndrome, Cardiovascular phenotype, Brugada syndrome
Health Risk
RS1177831483
Conflicting classifications of pathogenicity
Brugada syndrome, Cardiovascular phenotype, Brugada syndrome
Health Risk
RS1278228854
Conflicting classifications of pathogenicity
Brugada syndrome, Cardiovascular phenotype, Brugada syndrome
Health Risk
RS1315864029
Conflicting classifications of pathogenicity
Brugada syndrome, Cardiovascular phenotype, Brugada syndrome
Health Risk
RS1324200224
Conflicting classifications of pathogenicity
Cardiovascular phenotype, Brugada syndrome, Cardiovascular phenotype
Health Risk
RS137906740
Conflicting classifications of pathogenicity
Brugada syndrome, Episodic pain syndrome, familial
Health Risk
RS138404783
Conflicting classifications of pathogenicity
Episodic pain syndrome, familial, 2
Health Risk
RS138751097
Conflicting classifications of pathogenicity
Brugada syndrome, Cardiovascular phenotype, Brugada syndrome
Health Risk
RS138832868
Conflicting classifications of pathogenicity
Brugada syndrome 1, Episodic pain syndrome, familial
Health Risk
RS1393646938
Conflicting classifications of pathogenicity
Cardiovascular phenotype, Brugada syndrome, Cardiovascular phenotype
Health Risk
RS1398369804
Conflicting classifications of pathogenicity
Brugada syndrome, Cardiovascular phenotype, Brugada syndrome
Health Risk
RS139861061
Conflicting classifications of pathogenicity
Brugada syndrome, Episodic pain syndrome, familial
Health Risk
All Variants (183)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS549795936 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, SCN10A-related disorder |
| RS553784643 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS554062977 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Brugada syndrome 1, Cardiovascular phenotype |
| RS558639346 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Episodic pain syndrome, familial |
| RS559166014 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS560631745 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS561166361 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Brugada syndrome, Cardiovascular phenotype |
| RS563110484 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, SCN10A-related disorder, Brugada syndrome |
| RS564943632 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS567269429 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Brugada syndrome |
| RS576503650 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Brugada syndrome, Cardiovascular phenotype |
| RS576999040 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Brugada syndrome, Cardiovascular phenotype |
| RS7374804 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS747114420 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS747321219 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Episodic pain syndrome |
| RS747486328 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS749000689 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS753004431 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS753292241 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS754088416 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Episodic pain syndrome |
| RS755345820 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS755728923 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS756848600 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, SCN10A-related disorder |
| RS757136675 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS757155232 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS757294772 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS757704367 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS758230618 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Brugada syndrome, Cardiovascular phenotype |
| RS758877832 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Cardiovascular phenotype |
| RS759458296 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS759842238 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS75991777 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome 1, Cardiovascular phenotype, Brugada syndrome 1 |
| RS759953813 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS760270839 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS760702095 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS763674655 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS763764330 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS764095900 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS764168768 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS764191883 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, SCN10A-related disorder |
| RS764260671 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Brugada syndrome, Cardiovascular phenotype |
| RS764654464 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS765684724 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Episodic pain syndrome |
| RS766017851 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Episodic pain syndrome, familial |
| RS766044564 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Brugada syndrome, Cardiovascular phenotype |
| RS766280701 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Episodic pain syndrome, familial |
| RS767177596 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS767267531 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS767815241 | Health Risk | Conflicting classifications of pathogenicity | Brugada syndrome, Cardiovascular phenotype, Brugada syndrome |
| RS769399952 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Brugada syndrome, Cardiovascular phenotype |