SAMHD1 Chromosome 20
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
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What This Gene Does
This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010]
Gene Info
Gene Group
Sterile alpha motif domain containing
Locus Type
gene with protein product
Location
20q11.23
Ensembl
ENSG00000101347
Associated Conditions (8)
Aicardi-Goutieres syndrome 5
Inborn genetic diseases
Chilblain lupus 2
Aicardi Goutieres syndrome
Multiple myeloma
Melanoma
SAMHD1-related disorder
Cerebral palsy
Key Variants
RS1356154563
Conflicting classifications of pathogenicity
Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5
Health Risk
RS1399199211
Conflicting classifications of pathogenicity
Inborn genetic diseases, Aicardi-Goutieres syndrome 5, Inborn genetic diseases
Health Risk
RS142162198
Conflicting classifications of pathogenicity
Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Aicardi-Goutieres syndrome 5
Health Risk
RS142393072
Conflicting classifications of pathogenicity
Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Aicardi Goutieres syndrome
Health Risk
RS143588093
Conflicting classifications of pathogenicity
Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Chilblain lupus 2
Health Risk
RS1448113794
Conflicting classifications of pathogenicity
Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Aicardi-Goutieres syndrome 5
Health Risk
RS145735112
Conflicting classifications of pathogenicity
Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Aicardi Goutieres syndrome
Health Risk
RS147220022
Conflicting classifications of pathogenicity
Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Chilblain lupus 2
Health Risk
RS147240777
Conflicting classifications of pathogenicity
Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Aicardi Goutieres syndrome
Health Risk
RS150713148
Conflicting classifications of pathogenicity
Aicardi Goutieres syndrome, Aicardi-Goutieres syndrome 5, Inborn genetic diseases
Health Risk
RS17853622
Conflicting classifications of pathogenicity
Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Aicardi-Goutieres syndrome 5
Health Risk
RS199721283
Conflicting classifications of pathogenicity
Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Chilblain lupus 2
Health Risk
All Variants (142)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1356154563 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS1399199211 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Aicardi-Goutieres syndrome 5, Inborn genetic diseases |
| RS142162198 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Aicardi-Goutieres syndrome 5 |
| RS142393072 | Health Risk | Conflicting classifications of pathogenicity | Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Aicardi Goutieres syndrome |
| RS143588093 | Health Risk | Conflicting classifications of pathogenicity | Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Chilblain lupus 2 |
| RS1448113794 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Aicardi-Goutieres syndrome 5 |
| RS145735112 | Health Risk | Conflicting classifications of pathogenicity | Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Aicardi Goutieres syndrome |
| RS147220022 | Health Risk | Conflicting classifications of pathogenicity | Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Chilblain lupus 2 |
| RS147240777 | Health Risk | Conflicting classifications of pathogenicity | Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Aicardi Goutieres syndrome |
| RS150713148 | Health Risk | Conflicting classifications of pathogenicity | Aicardi Goutieres syndrome, Aicardi-Goutieres syndrome 5, Inborn genetic diseases |
| RS17853622 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Aicardi-Goutieres syndrome 5 |
| RS199721283 | Health Risk | Conflicting classifications of pathogenicity | Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Chilblain lupus 2 |
| RS199896513 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Inborn genetic diseases, Aicardi-Goutieres syndrome 5 |
| RS200458478 | Health Risk | Conflicting classifications of pathogenicity | Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Chilblain lupus 2 |
| RS202024857 | Health Risk | Conflicting classifications of pathogenicity | Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Chilblain lupus 2 |
| RS2515217377 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Aicardi-Goutieres syndrome 5 |
| RS368233437 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Aicardi-Goutieres syndrome 5 |
| RS373079404 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Aicardi Goutieres syndrome |
| RS750359968 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Aicardi-Goutieres syndrome 5, Inborn genetic diseases |
| RS756532676 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Aicardi-Goutieres syndrome 5 |
| RS765879627 | Health Risk | Conflicting classifications of pathogenicity | Aicardi Goutieres syndrome, Aicardi-Goutieres syndrome 5, Aicardi Goutieres syndrome |
| RS767413799 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Aicardi-Goutieres syndrome 5 |
| RS767971429 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Aicardi Goutieres syndrome, Inborn genetic diseases |
| RS769968442 | Health Risk | Conflicting classifications of pathogenicity | Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Chilblain lupus 2 |
| RS775726168 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Aicardi Goutieres syndrome |
| RS775762131 | Health Risk | Conflicting classifications of pathogenicity | Chilblain lupus 2, Aicardi-Goutieres syndrome 5, Aicardi Goutieres syndrome |
| RS778647626 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Aicardi-Goutieres syndrome 5 |
| RS868763843 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS923362391 | Health Risk | Conflicting classifications of pathogenicity | Aicardi-Goutieres syndrome 5, Chilblain lupus 2, Inborn genetic diseases |
| RS1192315307 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi Goutieres syndrome, Aicardi-Goutieres syndrome 5 |
| RS1251155562 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS1303667371 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS1410153662 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS1473874262 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS1600394490 | Health Risk | Likely pathogenic | Multiple myeloma, Multiple myeloma |
| RS1601141002 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS1700306908 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS1990238054 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Melanoma, Aicardi-Goutieres syndrome 5 |
| RS2146117027 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS2146119643 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS2146137671 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS2515229076 | Health Risk | Likely pathogenic | Aicardi Goutieres syndrome, Aicardi Goutieres syndrome |
| RS2515229165 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS2515244359 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS2515254153 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS2515258417 | Health Risk | Likely pathogenic | SAMHD1-related disorder, SAMHD1-related disorder |
| RS2515264387 | Health Risk | Likely pathogenic | Inborn genetic diseases, Aicardi-Goutieres syndrome 5, Inborn genetic diseases |
| RS373731440 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS374561117 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Aicardi-Goutieres syndrome 5 |
| RS515726145 | Health Risk | Likely pathogenic | Aicardi-Goutieres syndrome 5, Inborn genetic diseases, Aicardi-Goutieres syndrome 5 |