SALL1 Chromosome 16

Spalt like transcription factor 1
129 variants 129 Health Risk

Upload your DNA to see your personal genotypes for variants in SALL1.

What This Gene Does
The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Zinc fingers C2H2-type
Locus Type
gene with protein product
Location
16q12.1
Ensembl
ENSG00000103449
Associated Conditions (9)
Townes-Brocks syndrome 1
Townes syndrome
SALL1-related disorder
Congenital anomaly of kidney and urinary tract
Inborn genetic diseases
Sarcoma
Malignant tumor of esophagus
Townes-Brocks-branchiootorenal-like syndrome
Hearing impairment
Key Variants
All Variants (129)
RSID Category Clinical Significance Conditions
RS1057518131 Health Risk Likely pathogenic
RS1597228490 Health Risk Likely pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS1597228550 Health Risk Likely pathogenic
RS1597229025 Health Risk Likely pathogenic
RS1597229151 Health Risk Likely pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS2143436744 Health Risk Likely pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS2143442678 Health Risk Likely pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS2143452445 Health Risk Likely pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS2506476542 Health Risk Likely pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS2506487918 Health Risk Likely pathogenic SALL1-related disorder, SALL1-related disorder
RS2506495554 Health Risk Likely pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS2506498891 Health Risk Likely pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS2506498947 Health Risk Likely pathogenic SALL1-related disorder, SALL1-related disorder
RS776856200 Health Risk Likely pathogenic Congenital anomaly of kidney and urinary tract, Congenital anomaly of kidney and urinary tract
RS780221020 Health Risk Likely pathogenic
RS104894535 Health Risk Pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS104894538 Health Risk Pathogenic Townes-Brocks-branchiootorenal-like syndrome, Townes syndrome, Townes-Brocks syndrome 1
RS1057518232 Health Risk Pathogenic
RS1057518273 Health Risk Pathogenic
RS1064793257 Health Risk Pathogenic Townes-Brocks syndrome 1, Townes syndrome, SALL1-related disorder
RS1064796960 Health Risk Pathogenic
RS1085307143 Health Risk Pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS1197587893 Health Risk Pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS137853084 Health Risk Pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS1555475106 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS1555475120 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS1555475275 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS1555475319 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS1555475334 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS1555475342 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS1567316325 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS1597228188 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS1597228568 Health Risk Pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS1597229721 Health Risk Pathogenic Townes-Brocks-branchiootorenal-like syndrome, Townes-Brocks-branchiootorenal-like syndrome
RS1597230241 Health Risk Pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS1597230288 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS1597230341 Health Risk Pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS1597230349 Health Risk Pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS1597230687 Health Risk Pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS1597230909 Health Risk Pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS188182072 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS1962410902 Health Risk Pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS1962426127 Health Risk Pathogenic
RS1962428520 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS1962442258 Health Risk Pathogenic Inborn genetic diseases, Townes syndrome, Inborn genetic diseases
RS2143446012 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS2143446286 Health Risk Pathogenic Townes-Brocks syndrome 1, Townes-Brocks syndrome 1
RS2143448019 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS2143448046 Health Risk Pathogenic Townes syndrome, Townes syndrome
RS2143448771 Health Risk Pathogenic Townes syndrome, Hearing impairment, Townes syndrome
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