RRP8 Chromosome 11
Ribosomal RNA processing 8
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What This Gene Does
Enables methylated histone binding activity. Involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Acts upstream of with a negative effect on regulation of G1 to G0 transition. Located in several cellular components, including cytosol; nuclear lumen; and rDNA heterochromatin. Part of eNoSc complex. [provided by Alliance of Genome Resources, Apr 2025]
Gene Info
Gene Group
"eNoSC complex|Ribosomal biogenesis factors|7BS N1-adenosine RNA methyltransferases|DNA/RNA methyltransferases"
Locus Type
gene with protein product
Location
11p15.4
Ensembl
ENSG00000132275
Associated Conditions (1)
Autism spectrum disorder
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS759913983 | Health Risk | association | Autism spectrum disorder, Autism spectrum disorder |