RPA4 Chromosome X
Replication protein A4
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What This Gene Does
This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]
Gene Info
Gene Group
Nucleotide excision repair
Locus Type
gene with protein product
Location
Xq21.33
Ensembl
ENSG00000204086
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS200380831 | Health Risk | Conflicting classifications of pathogenicity | — |