RNASET2 Chromosome 6

Ribonuclease T2

18 variants 18 Health Risk

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What This Gene Does

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]

Associated Conditions (2)

Inborn genetic diseases

Cystic leukoencephalopathy without megalencephaly

Key Variants

RS149426644

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

RS184572250

Conflicting classifications of pathogenicity

Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly

Health Risk

RS202105909

Conflicting classifications of pathogenicity

Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly

Health Risk

RS35517174

Conflicting classifications of pathogenicity

Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly

Health Risk

RS370545130

Conflicting classifications of pathogenicity

Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly

Health Risk

RS74546166

Conflicting classifications of pathogenicity

Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly

Health Risk

RS750265990

Conflicting classifications of pathogenicity

Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly

Health Risk

RS763011032

Conflicting classifications of pathogenicity

Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly

Health Risk

RS763295910

Conflicting classifications of pathogenicity

Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly

Health Risk

RS2128646702

Likely pathogenic

Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly

Health Risk

RS121918137

Pathogenic

Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly

Health Risk

RS1434250650

Pathogenic

Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly

Health Risk

All Variants (18)

RSID	Category	Clinical Significance	Conditions
RS149426644	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS184572250	Health Risk	Conflicting classifications of pathogenicity	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS202105909	Health Risk	Conflicting classifications of pathogenicity	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS35517174	Health Risk	Conflicting classifications of pathogenicity	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS370545130	Health Risk	Conflicting classifications of pathogenicity	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS74546166	Health Risk	Conflicting classifications of pathogenicity	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS750265990	Health Risk	Conflicting classifications of pathogenicity	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS763011032	Health Risk	Conflicting classifications of pathogenicity	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS763295910	Health Risk	Conflicting classifications of pathogenicity	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS2128646702	Health Risk	Likely pathogenic	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS121918137	Health Risk	Pathogenic	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS1434250650	Health Risk	Pathogenic	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS1583242286	Health Risk	Pathogenic	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS2128645753	Health Risk	Pathogenic	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS2128645761	Health Risk	Pathogenic	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS2483216603	Health Risk	Pathogenic	Cystic leukoencephalopathy without megalencephaly, Cystic leukoencephalopathy without megalencephaly
RS367656044	Health Risk	Pathogenic	—
RS750669368	Health Risk	Pathogenic	Inborn genetic diseases, Inborn genetic diseases