RNASEL Chromosome 1
Ribonuclease L
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What This Gene Does
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Nov 2021]
Gene Info
Gene Group
"Ankyrin repeat domain containing|Endoribonucleases"
Locus Type
gene with protein product
Location
1q25.3
Ensembl
ENSG00000135828
Associated Conditions (5)
Prostate cancer
hereditary
1
RNASEL-related disorder
Ovarian cancer
Key Variants
RS74315364
Conflicting classifications of pathogenicity
Prostate cancer, hereditary, 1
Health Risk
RS2102370520
Likely pathogenic
Ovarian cancer, Ovarian cancer
Health Risk
RS557182938
Likely pathogenic
Ovarian cancer, Ovarian cancer
Health Risk
RS74315365
Pathogenic
Prostate cancer, hereditary, 1
Health Risk
All Variants (4)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS74315364 | Health Risk | Conflicting classifications of pathogenicity | Prostate cancer, hereditary, 1 |
| RS2102370520 | Health Risk | Likely pathogenic | Ovarian cancer, Ovarian cancer |
| RS557182938 | Health Risk | Likely pathogenic | Ovarian cancer, Ovarian cancer |
| RS74315365 | Health Risk | Pathogenic | Prostate cancer, hereditary, 1 |