RIPK2 Chromosome 8

Receptor interacting serine/threonine kinase 2
2 variants 2 Health Risk

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What This Gene Does
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"Caspase recruitment domain containing|Receptor interacting serine/threonine kinase family"
Locus Type
gene with protein product
Location
8q21.3
Ensembl
ENSG00000104312
Associated Conditions (3)
Leprosy
susceptibility to
1
Key Variants
RS40457
Uncertain risk allele
Leprosy, susceptibility to, 1
Health Risk
RS42490
Uncertain risk allele
Leprosy, susceptibility to, 1
Health Risk
All Variants (2)
RSID Category Clinical Significance Conditions
RS40457 Health Risk Uncertain risk allele Leprosy, susceptibility to, 1
RS42490 Health Risk Uncertain risk allele Leprosy, susceptibility to, 1
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