RCC1 Chromosome 1
Regulator of chromosome condensation 1
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What This Gene Does
Enables several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Involved in G1/S transition of mitotic cell cycle; regulation of mitotic nuclear division; and spindle organization. Located in chromatin; cytoplasm; and nuclear lumen. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2025]
Associated Conditions (2)
See cases
INFECTION-INDUCED ACUTE-ONSET AXONAL NEUROPATHY
Key Variants
RS1289362452
Likely pathogenic
See cases, See cases
Health Risk
RS2525349586
Likely pathogenic
See cases, See cases
Health Risk
RS2525347778
Pathogenic
See cases, See cases
Health Risk
RS777909472
Pathogenic/Likely pathogenic
INFECTION-INDUCED ACUTE-ONSET AXONAL NEUROPATHY, See cases, INFECTION-INDUCED ACUTE-ONSET AXONAL NEUROPATHY
Health Risk
All Variants (4)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1289362452 | Health Risk | Likely pathogenic | See cases, See cases |
| RS2525349586 | Health Risk | Likely pathogenic | See cases, See cases |
| RS2525347778 | Health Risk | Pathogenic | See cases, See cases |
| RS777909472 | Health Risk | Pathogenic/Likely pathogenic | INFECTION-INDUCED ACUTE-ONSET AXONAL NEUROPATHY, See cases, INFECTION-INDUCED ACUTE-ONSET AXONAL NEUROPATHY |