RAD51D Chromosome 17

RAD51 paralog D
368 variants 368 Health Risk

Upload your DNA to see your personal genotypes for variants in RAD51D.

What This Gene Does
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]
Gene Info
Gene Group
RAD51 paralogs
Locus Type
gene with protein product
Location
17q12
Ensembl
ENSG00000185379
Associated Conditions (30)
Breast-ovarian cancer
familial
susceptibility to
4
Hereditary cancer-predisposing syndrome
Hereditary breast ovarian cancer syndrome
Malignant tumor of breast
Breast and/or ovarian cancer
RAD51D-related disorder
Hereditary cancer
RAD51D-related cancer predisposition
Familial ovarian cancer
Deleterious RAD51D Gene Mutation
Breast cancer
Lynch syndrome 1
Anaplastic/large cell medulloblastoma
Gastric cancer
Hereditary site-specific ovarian cancer syndrome
Cancer or benign tumor
Ovarian neoplasm
+10 more conditions
Key Variants
RS1002032036
Conflicting classifications of pathogenicity
Breast-ovarian cancer, familial, susceptibility to
Health Risk
RS1060502957
Conflicting classifications of pathogenicity
Breast-ovarian cancer, familial, susceptibility to
Health Risk
RS1064794619
Conflicting classifications of pathogenicity
Breast-ovarian cancer, familial, susceptibility to
Health Risk
RS1064795057
Conflicting classifications of pathogenicity
Breast-ovarian cancer, familial, susceptibility to
Health Risk
RS113147933
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
Health Risk
RS115031549
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
Health Risk
RS1169894160
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
Health Risk
RS1185842552
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
Health Risk
RS1210620444
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
Health Risk
RS1210749655
Conflicting classifications of pathogenicity
Breast-ovarian cancer, familial, susceptibility to
Health Risk
RS1230625396
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
Health Risk
RS1235042092
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
Health Risk
All Variants (368)
RSID Category Clinical Significance Conditions
RS1567728649 Health Risk Pathogenic RAD51D-related disorder, Breast-ovarian cancer, familial
RS1567735277 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1597858243 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1597861892 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1597863362 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS1597876652 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS200009601 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS200487648 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2091536198 Health Risk Pathogenic Gastric cancer, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
RS2091564839 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2091565327 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2091602962 Health Risk Pathogenic Breast and/or ovarian cancer, Hereditary cancer-predisposing syndrome, Ovarian neoplasm
RS2091603173 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2091604825 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2091789001 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2091798919 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS2142409021 Health Risk Pathogenic Gastric cancer, Gastric cancer
RS2142411968 Health Risk Pathogenic Familial cancer of breast, Familial cancer of breast
RS2142412448 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142421220 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142428757 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142428821 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142429256 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142429527 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142429702 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142429748 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142433388 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142433535 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142434009 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2142436967 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142473486 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142473574 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142474239 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142474668 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142477410 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2142480422 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS2142480769 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509122809 Health Risk Pathogenic Gastric cancer, Gastric cancer
RS2509124437 Health Risk Pathogenic Gastric cancer, Gastric cancer
RS2509128875 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509129015 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509130471 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509135035 Health Risk Pathogenic Gastric cancer, Gastric cancer
RS2509135407 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509135478 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509137669 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509138759 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509142628 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509142706 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS2509142747 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
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