PPP6R2 Chromosome 22
Protein phosphatase 6 regulatory subunit 2
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What This Gene Does
The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]
Gene Info
Gene Group
"Protein phosphatase 6 regulatory subunits|Armadillo like helical domain containing"
Locus Type
gene with protein product
Location
22q13.33
Ensembl
ENSG00000100239
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS148637820 | Health Risk | Conflicting classifications of pathogenicity | — |