POLA2 Chromosome 11
DNA polymerase alpha 2, accessory subunit
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What This Gene Does
Predicted to enable DNA binding activity. Involved in DNA replication initiation and DNA replication, synthesis of primer. Located in ciliary basal body; cytosol; and nucleoplasm. Part of alpha DNA polymerase:primase complex. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
DNA polymerases
Locus Type
gene with protein product
Location
11q13.1
Ensembl
ENSG00000014138
Associated Conditions (1)
Telomere Biology Disorder
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1329580446 | Health Risk | Conflicting classifications of pathogenicity | Telomere Biology Disorder, Telomere Biology Disorder |
| RS777941351 | Health Risk | Likely pathogenic | Telomere Biology Disorder, Telomere Biology Disorder |