PLEKHG3 Chromosome 14
Pleckstrin homology and RhoGEF domain containing G3
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What This Gene Does
Enables actin binding activity. Involved in regulation of cell migration and regulation of establishment of cell polarity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
"Pleckstrin homology domain containing|Dbl family Rho GEFs"
Locus Type
gene with protein product
Location
14q23.3
Ensembl
ENSG00000126822
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS141719183 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS72724479 | Health Risk | Conflicting classifications of pathogenicity | — |