PLA2G2A Chromosome 1
Phospholipase A2 group IIA
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What This Gene Does
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Info
Gene Group
Phospholipases
Locus Type
gene with protein product
Location
1p36.13
Ensembl
ENSG00000188257
Associated Conditions (1)
Familial colorectal cancer
Key Variants
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS587776800 | Health Risk | Pathogenic | Familial colorectal cancer, Familial colorectal cancer |