PHB1 Chromosome 17
Prohibitin 1
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What This Gene Does
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Info
Gene Group
Mitochondrial nucleoid associated proteins
Locus Type
gene with protein product
Location
17q21.33
Ensembl
ENSG00000167085
Associated Conditions (2)
Breast cancer
susceptibility to
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS112294663 | Health Risk | risk factor | Breast cancer, susceptibility to, Breast cancer |