PDYN Chromosome 20
Prodynorphin
Upload your DNA to see your personal genotypes for variants in PDYN.
What This Gene Does
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Info
Gene Group
Neuropeptides
Locus Type
gene with protein product
Location
20p13
Ensembl
ENSG00000101327
Associated Conditions (2)
Inborn genetic diseases
Spinocerebellar ataxia type 23
Key Variants
RS1028619685
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS1171241754
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS138498390
Conflicting classifications of pathogenicity
Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23
Health Risk
RS144748816
Conflicting classifications of pathogenicity
Health Risk
RS147355936
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS185551108
Conflicting classifications of pathogenicity
Spinocerebellar ataxia type 23, Inborn genetic diseases, Spinocerebellar ataxia type 23
Health Risk
RS201204862
Conflicting classifications of pathogenicity
Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23
Health Risk
RS201585283
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS267606941
Conflicting classifications of pathogenicity
Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23
Health Risk
RS376124198
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS565210312
Conflicting classifications of pathogenicity
Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23
Health Risk
RS567558964
Conflicting classifications of pathogenicity
Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23
Health Risk
All Variants (18)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1028619685 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS1171241754 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS138498390 | Health Risk | Conflicting classifications of pathogenicity | Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23 |
| RS144748816 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS147355936 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS185551108 | Health Risk | Conflicting classifications of pathogenicity | Spinocerebellar ataxia type 23, Inborn genetic diseases, Spinocerebellar ataxia type 23 |
| RS201204862 | Health Risk | Conflicting classifications of pathogenicity | Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23 |
| RS201585283 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS267606941 | Health Risk | Conflicting classifications of pathogenicity | Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23 |
| RS376124198 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS565210312 | Health Risk | Conflicting classifications of pathogenicity | Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23 |
| RS567558964 | Health Risk | Conflicting classifications of pathogenicity | Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23 |
| RS748307861 | Health Risk | Conflicting classifications of pathogenicity | Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23 |
| RS752953257 | Health Risk | Conflicting classifications of pathogenicity | Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23 |
| RS767631485 | Health Risk | Conflicting classifications of pathogenicity | Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23 |
| RS769461186 | Health Risk | Conflicting classifications of pathogenicity | Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23 |
| RS201486601 | Health Risk | Likely pathogenic | Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23 |
| RS267606939 | Health Risk | Pathogenic | Spinocerebellar ataxia type 23, Spinocerebellar ataxia type 23 |