PDLIM4 Chromosome 5
PDZ and LIM domain 4
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What This Gene Does
Enables alpha-actinin binding activity; protein homodimerization activity; and protein phosphatase binding activity. Involved in actin cytoskeleton organization. Located in several cellular components, including lamellipodium; perinuclear region of cytoplasm; and stress fiber. Part of filamentous actin. Implicated in osteoporosis. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
"LIM domain containing|PDZ domain containing"
Locus Type
gene with protein product
Location
5q31.1
Ensembl
ENSG00000131435
Associated Conditions (1)
BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 15
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS453602 | Health Risk | risk factor | BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 15, BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 15 |