PARP10 Chromosome 8
Poly(ADP-ribose) polymerase family member 10
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What This Gene Does
Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
Gene Info
Gene Group
Poly(ADP-ribose) polymerases
Locus Type
gene with protein product
Location
8q24.3
Ensembl
ENSG00000178685
Associated Conditions (1)
Developmental delay
Key Variants
All Variants (3)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS139271648 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS200251958 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1587459606 | Health Risk | Likely pathogenic | Developmental delay, Developmental delay |