PADI4 Chromosome 1
Peptidyl arginine deiminase 4
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What This Gene Does
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Peptidyl arginine deiminases
Locus Type
gene with protein product
Location
1p36.13
Ensembl
ENSG00000159339
Associated Conditions (3)
Rheumatoid arthritis
Abnormal pulmonary interstitial morphology
PADI4-related disorder
Key Variants
RS1557787212
association
Rheumatoid arthritis, Rheumatoid arthritis
Health Risk
RS2240340
association
Rheumatoid arthritis, Rheumatoid arthritis
Health Risk
RS11203366
Benign; association
Rheumatoid arthritis, Abnormal pulmonary interstitial morphology, PADI4-related disorder
Health Risk
RS11203367
Benign; association
Rheumatoid arthritis, Abnormal pulmonary interstitial morphology, PADI4-related disorder
Health Risk
RS1748033
Benign; association
Rheumatoid arthritis, Abnormal pulmonary interstitial morphology, PADI4-related disorder
Health Risk
RS874881
Benign; association
Rheumatoid arthritis, Abnormal pulmonary interstitial morphology, PADI4-related disorder
Health Risk
All Variants (6)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1557787212 | Health Risk | association | Rheumatoid arthritis, Rheumatoid arthritis |
| RS2240340 | Health Risk | association | Rheumatoid arthritis, Rheumatoid arthritis |
| RS11203366 | Health Risk | Benign; association | Rheumatoid arthritis, Abnormal pulmonary interstitial morphology, PADI4-related disorder |
| RS11203367 | Health Risk | Benign; association | Rheumatoid arthritis, Abnormal pulmonary interstitial morphology, PADI4-related disorder |
| RS1748033 | Health Risk | Benign; association | Rheumatoid arthritis, Abnormal pulmonary interstitial morphology, PADI4-related disorder |
| RS874881 | Health Risk | Benign; association | Rheumatoid arthritis, Abnormal pulmonary interstitial morphology, PADI4-related disorder |