OPRM1 Chromosome 6
Opioid receptor mu 1
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What This Gene Does
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
Gene Info
Gene Group
Opioid receptors
Locus Type
gene with protein product
Location
6q25.2
Ensembl
ENSG00000112038
Associated Conditions (4)
Tramadol response
Opioid dependence
susceptibility to
1
Key Variants
RS1014331595
drug response
Tramadol response, Tramadol response
Drug Response
RS1017227710
drug response
Tramadol response, Tramadol response
Drug Response
RS1033852015
drug response
Tramadol response, Tramadol response
Drug Response
RS113270588
drug response
Tramadol response, Tramadol response
Drug Response
RS114492858
drug response
Tramadol response, Tramadol response
Drug Response
RS11575858
drug response
Tramadol response, Tramadol response
Drug Response
RS115788842
drug response
Tramadol response, Tramadol response
Drug Response
RS1160295304
drug response
Tramadol response, Tramadol response
Drug Response
RS1160455955
drug response
Tramadol response, Tramadol response
Drug Response
RS1169090293
drug response
Tramadol response, Tramadol response
Drug Response
RS1178930557
drug response
Tramadol response, Tramadol response
Drug Response
RS1183268180
drug response
Tramadol response, Tramadol response
Drug Response
All Variants (460)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1583502117 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583502202 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583502383 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583502552 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583576485 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583576504 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583576560 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583576581 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583576770 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583577388 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583577432 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583577918 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583578066 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583578847 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583579146 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583579223 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583579274 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583579471 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583579544 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583579747 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583579780 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583579976 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583580011 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583580059 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583580161 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583580176 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583580562 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583580623 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583580736 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583581065 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583581242 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583581365 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583581395 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583581810 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583582181 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583582271 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583582311 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583582329 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583582348 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583582470 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583582588 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583582674 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583583367 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583583459 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583583588 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583583598 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583583705 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583583861 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583583986 | Drug Response | drug response | Tramadol response, Tramadol response |
| RS1583584064 | Drug Response | drug response | Tramadol response, Tramadol response |