OAS1 Chromosome 12
2'-5'-oligoadenylate synthetase 1
Upload your DNA to see your personal genotypes for variants in OAS1.
What This Gene Does
This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cellular processes like cell growth and apoptosis. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection, including SARS-CoV-2, and diabetes mellitus, type 1. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, May 2022]
Gene Info
Gene Group
2'-5'-oligoadenylate synthetase family
Locus Type
gene with protein product
Location
12q24.13
Ensembl
ENSG00000089127
Associated Conditions (2)
Pulmonary alveolar proteinosis with hypogammaglobulinemia
OAS1-related disorder
Key Variants
RS138105298
Conflicting classifications of pathogenicity
Health Risk
RS138921278
Conflicting classifications of pathogenicity
Pulmonary alveolar proteinosis with hypogammaglobulinemia, Pulmonary alveolar proteinosis with hypogammaglobulinemia
Health Risk
RS140799151
Conflicting classifications of pathogenicity
Health Risk
RS142314177
Conflicting classifications of pathogenicity
Pulmonary alveolar proteinosis with hypogammaglobulinemia, Pulmonary alveolar proteinosis with hypogammaglobulinemia
Health Risk
RS142847241
Conflicting classifications of pathogenicity
Health Risk
RS146339735
Conflicting classifications of pathogenicity
OAS1-related disorder, OAS1-related disorder
Health Risk
RS148741042
Conflicting classifications of pathogenicity
Health Risk
RS148820389
Conflicting classifications of pathogenicity
Pulmonary alveolar proteinosis with hypogammaglobulinemia, Pulmonary alveolar proteinosis with hypogammaglobulinemia
Health Risk
RS201971047
Conflicting classifications of pathogenicity
Health Risk
RS2043462968
Conflicting classifications of pathogenicity
Health Risk
RS2136321241
Conflicting classifications of pathogenicity
Health Risk
RS372813548
Conflicting classifications of pathogenicity
Health Risk
All Variants (22)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS138105298 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS138921278 | Health Risk | Conflicting classifications of pathogenicity | Pulmonary alveolar proteinosis with hypogammaglobulinemia, Pulmonary alveolar proteinosis with hypogammaglobulinemia |
| RS140799151 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS142314177 | Health Risk | Conflicting classifications of pathogenicity | Pulmonary alveolar proteinosis with hypogammaglobulinemia, Pulmonary alveolar proteinosis with hypogammaglobulinemia |
| RS142847241 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS146339735 | Health Risk | Conflicting classifications of pathogenicity | OAS1-related disorder, OAS1-related disorder |
| RS148741042 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS148820389 | Health Risk | Conflicting classifications of pathogenicity | Pulmonary alveolar proteinosis with hypogammaglobulinemia, Pulmonary alveolar proteinosis with hypogammaglobulinemia |
| RS201971047 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS2043462968 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS2136321241 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS372813548 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS373282263 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS527675104 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS528923373 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS766882379 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS768335993 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS770540128 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS779611860 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS779775183 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1555223390 | Health Risk | Likely pathogenic | Pulmonary alveolar proteinosis with hypogammaglobulinemia, Pulmonary alveolar proteinosis with hypogammaglobulinemia |
| RS2136295939 | Health Risk | Pathogenic | Pulmonary alveolar proteinosis with hypogammaglobulinemia, Pulmonary alveolar proteinosis with hypogammaglobulinemia |