NTNG2 Chromosome 9
Netrin G2
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What This Gene Does
Predicted to be involved in axonogenesis; regulation of cell projection organization; and regulation of neuron migration. Predicted to be located in plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone membrane. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
Netrins
Locus Type
gene with protein product
Location
9q34.13
Ensembl
ENSG00000196358
Associated Conditions (11)
Neurodevelopmental disorder with behavioral abnormalities
absent speech
and hypotonia
Developmental and epileptic encephalopathy
27
Neurodevelopmental disorder
Abnormality of the nervous system
Stereotypical hand wringing
Areflexia
Generalized hypotonia
Global developmental delay
Key Variants
RS1840794100
Conflicting classifications of pathogenicity
Neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia
Health Risk
RS1227245973
Likely pathogenic
Neurodevelopmental disorder, Neurodevelopmental disorder with behavioral abnormalities, absent speech
Health Risk
RS2130728045
Likely pathogenic
Abnormality of the nervous system, Abnormality of the nervous system
Health Risk
RS1589441428
Pathogenic
Stereotypical hand wringing, Areflexia, Generalized hypotonia
Health Risk
RS1589440982
Pathogenic/Likely pathogenic
Neurodevelopmental disorder, Neurodevelopmental disorder with behavioral abnormalities, absent speech
Health Risk
RS1589441229
Pathogenic/Likely pathogenic
Neurodevelopmental disorder, Neurodevelopmental disorder with behavioral abnormalities, absent speech
Health Risk
RS1589568476
Pathogenic/Likely pathogenic
Neurodevelopmental disorder, Neurodevelopmental disorder with behavioral abnormalities, absent speech
Health Risk
RS1589576879
Pathogenic/Likely pathogenic
Neurodevelopmental disorder, Neurodevelopmental disorder with behavioral abnormalities, absent speech
Health Risk
All Variants (8)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1840794100 | Health Risk | Conflicting classifications of pathogenicity | Neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia |
| RS1227245973 | Health Risk | Likely pathogenic | Neurodevelopmental disorder, Neurodevelopmental disorder with behavioral abnormalities, absent speech |
| RS2130728045 | Health Risk | Likely pathogenic | Abnormality of the nervous system, Abnormality of the nervous system |
| RS1589441428 | Health Risk | Pathogenic | Stereotypical hand wringing, Areflexia, Generalized hypotonia |
| RS1589440982 | Health Risk | Pathogenic/Likely pathogenic | Neurodevelopmental disorder, Neurodevelopmental disorder with behavioral abnormalities, absent speech |
| RS1589441229 | Health Risk | Pathogenic/Likely pathogenic | Neurodevelopmental disorder, Neurodevelopmental disorder with behavioral abnormalities, absent speech |
| RS1589568476 | Health Risk | Pathogenic/Likely pathogenic | Neurodevelopmental disorder, Neurodevelopmental disorder with behavioral abnormalities, absent speech |
| RS1589576879 | Health Risk | Pathogenic/Likely pathogenic | Neurodevelopmental disorder, Neurodevelopmental disorder with behavioral abnormalities, absent speech |