NRROS Chromosome 3
Negative regulator of reactive oxygen species
Upload your DNA to see your personal genotypes for variants in NRROS.
What This Gene Does
Enables transforming growth factor beta binding activity. Predicted to be involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta receptor signaling pathway. Located in cell surface. [provided by Alliance of Genome Resources, Jul 2025]
Associated Conditions (5)
Seizures
early-onset
with neurodegeneration and brain calcifications
Inborn genetic diseases
NRROS-related disorder
Key Variants
RS140967612
Conflicting classifications of pathogenicity
Seizures, early-onset, with neurodegeneration and brain calcifications
Health Risk
RS749997451
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS1201594317
Likely pathogenic
Seizures, early-onset, with neurodegeneration and brain calcifications
Health Risk
RS1239560651
Likely pathogenic
NRROS-related disorder, NRROS-related disorder
Health Risk
RS1737685202
Likely pathogenic
Seizures, early-onset, with neurodegeneration and brain calcifications
Health Risk
RS2474180806
Likely pathogenic
Seizures, early-onset, with neurodegeneration and brain calcifications
Health Risk
RS1324029062
Pathogenic
Seizures, early-onset, with neurodegeneration and brain calcifications
Health Risk
RS1737495759
Pathogenic
Seizures, early-onset, with neurodegeneration and brain calcifications
Health Risk
RS1737672350
Pathogenic
Seizures, early-onset, with neurodegeneration and brain calcifications
Health Risk
RS1737677036
Pathogenic
Seizures, early-onset, with neurodegeneration and brain calcifications
Health Risk
RS2108643149
Pathogenic
Seizures, early-onset, with neurodegeneration and brain calcifications
Health Risk
RS762737130
Pathogenic
Seizures, early-onset, with neurodegeneration and brain calcifications
Health Risk
All Variants (13)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS140967612 | Health Risk | Conflicting classifications of pathogenicity | Seizures, early-onset, with neurodegeneration and brain calcifications |
| RS749997451 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS1201594317 | Health Risk | Likely pathogenic | Seizures, early-onset, with neurodegeneration and brain calcifications |
| RS1239560651 | Health Risk | Likely pathogenic | NRROS-related disorder, NRROS-related disorder |
| RS1737685202 | Health Risk | Likely pathogenic | Seizures, early-onset, with neurodegeneration and brain calcifications |
| RS2474180806 | Health Risk | Likely pathogenic | Seizures, early-onset, with neurodegeneration and brain calcifications |
| RS1324029062 | Health Risk | Pathogenic | Seizures, early-onset, with neurodegeneration and brain calcifications |
| RS1737495759 | Health Risk | Pathogenic | Seizures, early-onset, with neurodegeneration and brain calcifications |
| RS1737672350 | Health Risk | Pathogenic | Seizures, early-onset, with neurodegeneration and brain calcifications |
| RS1737677036 | Health Risk | Pathogenic | Seizures, early-onset, with neurodegeneration and brain calcifications |
| RS2108643149 | Health Risk | Pathogenic | Seizures, early-onset, with neurodegeneration and brain calcifications |
| RS762737130 | Health Risk | Pathogenic | Seizures, early-onset, with neurodegeneration and brain calcifications |
| RS868389022 | Health Risk | Pathogenic | Seizures, early-onset, with neurodegeneration and brain calcifications |