NRP2 Chromosome 2
Neuropilin 2
Upload your DNA to see your personal genotypes for variants in NRP2.
What This Gene Does
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Jul 2021]
Associated Conditions (2)
NRP2-related disorder
Inborn genetic diseases
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS910717989 | Health Risk | Conflicting classifications of pathogenicity | NRP2-related disorder, NRP2-related disorder |
| RS779617179 | Health Risk | Likely pathogenic | Inborn genetic diseases, NRP2-related disorder, Inborn genetic diseases |