NRAP Chromosome 10
Nebulin related anchoring protein
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What This Gene Does
Predicted to enable actin filament binding activity and muscle alpha-actinin binding activity. Predicted to be involved in cardiac muscle thin filament assembly. Predicted to be located in fascia adherens and muscle tendon junction. Predicted to be active in Z disc. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
"LIM domain containing|Nebulin family"
Locus Type
gene with protein product
Location
10q25.3
Ensembl
ENSG00000197893
Associated Conditions (4)
NRAP-related disorder
Inborn genetic diseases
Cardiovascular phenotype
Primary dilated cardiomyopathy
Key Variants
RS112597942
Conflicting classifications of pathogenicity
NRAP-related disorder, NRAP-related disorder
Health Risk
RS11575799
Conflicting classifications of pathogenicity
Inborn genetic diseases, NRAP-related disorder, Inborn genetic diseases
Health Risk
RS146676158
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS148504118
Conflicting classifications of pathogenicity
Inborn genetic diseases, NRAP-related disorder, Inborn genetic diseases
Health Risk
RS150955833
Conflicting classifications of pathogenicity
NRAP-related disorder, Cardiovascular phenotype, NRAP-related disorder
Health Risk
RS200591335
Conflicting classifications of pathogenicity
Inborn genetic diseases, NRAP-related disorder, Inborn genetic diseases
Health Risk
RS35222761
Conflicting classifications of pathogenicity
NRAP-related disorder, Cardiovascular phenotype, NRAP-related disorder
Health Risk
RS1592806462
Likely pathogenic
NRAP-related disorder, NRAP-related disorder
Health Risk
RS199673219
Likely pathogenic
Cardiovascular phenotype, Cardiovascular phenotype
Health Risk
RS2133935229
Likely pathogenic
Primary dilated cardiomyopathy, Primary dilated cardiomyopathy
Health Risk
RS369763684
Likely pathogenic
Health Risk
RS777578966
Likely pathogenic
Cardiovascular phenotype, Cardiovascular phenotype
Health Risk
All Variants (14)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS112597942 | Health Risk | Conflicting classifications of pathogenicity | NRAP-related disorder, NRAP-related disorder |
| RS11575799 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, NRAP-related disorder, Inborn genetic diseases |
| RS146676158 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS148504118 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, NRAP-related disorder, Inborn genetic diseases |
| RS150955833 | Health Risk | Conflicting classifications of pathogenicity | NRAP-related disorder, Cardiovascular phenotype, NRAP-related disorder |
| RS200591335 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, NRAP-related disorder, Inborn genetic diseases |
| RS35222761 | Health Risk | Conflicting classifications of pathogenicity | NRAP-related disorder, Cardiovascular phenotype, NRAP-related disorder |
| RS1592806462 | Health Risk | Likely pathogenic | NRAP-related disorder, NRAP-related disorder |
| RS199673219 | Health Risk | Likely pathogenic | Cardiovascular phenotype, Cardiovascular phenotype |
| RS2133935229 | Health Risk | Likely pathogenic | Primary dilated cardiomyopathy, Primary dilated cardiomyopathy |
| RS369763684 | Health Risk | Likely pathogenic | — |
| RS777578966 | Health Risk | Likely pathogenic | Cardiovascular phenotype, Cardiovascular phenotype |
| RS2493763082 | Health Risk | Pathogenic | — |
| RS868110215 | Health Risk | Pathogenic | — |