NPAT Chromosome 11
Nuclear protein, coactivator of histone transcription
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What This Gene Does
Enables transcription coactivator activity and transcription corepressor activity. Involved in cell cycle G1/S phase transition and positive regulation of transcription by RNA polymerase II. Located in Cajal body; Gemini of Cajal bodies; and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Associated Conditions (2)
Gastric cancer
NPAT-related disorder
Key Variants
RS1004229674
Conflicting classifications of pathogenicity
Health Risk
RS1035374602
Conflicting classifications of pathogenicity
Health Risk
RS115767553
Conflicting classifications of pathogenicity
Health Risk
RS1179164891
Conflicting classifications of pathogenicity
Health Risk
RS117925274
Conflicting classifications of pathogenicity
Health Risk
RS1261971124
Conflicting classifications of pathogenicity
Health Risk
RS140098074
Conflicting classifications of pathogenicity
Health Risk
RS145576966
Conflicting classifications of pathogenicity
Health Risk
RS1476780334
Conflicting classifications of pathogenicity
Health Risk
RS1481266372
Conflicting classifications of pathogenicity
Health Risk
RS1565311221
Conflicting classifications of pathogenicity
Health Risk
RS183625325
Conflicting classifications of pathogenicity
Health Risk
All Variants (36)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1004229674 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1035374602 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS115767553 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1179164891 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS117925274 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1261971124 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS140098074 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS145576966 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1476780334 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1481266372 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1565311221 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS183625325 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS184448909 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS185728047 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS200575398 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS200762365 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS201010866 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS201165741 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS201676429 | Health Risk | Conflicting classifications of pathogenicity | Gastric cancer, Gastric cancer |
| RS201716492 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS201987106 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS2134830919 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS2134834493 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS35504388 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS368304945 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS372699832 | Health Risk | Conflicting classifications of pathogenicity | NPAT-related disorder, NPAT-related disorder |
| RS544106839 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS572521227 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS754396326 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS758696196 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS761350756 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS763967156 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS765223725 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS769131892 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS781529538 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS867795975 | Health Risk | Conflicting classifications of pathogenicity | — |