NONO Chromosome X
Non-POU domain containing octamer binding
Upload your DNA to see your personal genotypes for variants in NONO.
What This Gene Does
This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]
Gene Info
Gene Group
"Protein phosphatase 1 regulatory subunits|RNA binding motif containing"
Locus Type
gene with protein product
Location
Xq13.1
Ensembl
ENSG00000147140
Associated Conditions (9)
Syndromic X-linked intellectual disability 34
Intellectual disability
Heart
malformation of
Medulloblastoma
Inborn genetic diseases
Neurodevelopmental delay
See cases
Non-ossifying fibromas with pathologic factures and X-linked intellectual disability
Key Variants
RS751131066
Conflicting classifications of pathogenicity
Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34
Health Risk
RS756534222
Conflicting classifications of pathogenicity
Syndromic X-linked intellectual disability 34, Intellectual disability, Syndromic X-linked intellectual disability 34
Health Risk
RS759524596
Conflicting classifications of pathogenicity
Health Risk
RS2031334549
Likely pathogenic
Heart, malformation of, Heart
Health Risk
RS2031456898
Likely pathogenic
Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34
Health Risk
RS2031508845
Likely pathogenic
Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34
Health Risk
RS2148033533
Likely pathogenic
Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34
Health Risk
RS2148033540
Likely pathogenic
Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34
Health Risk
RS2148040741
Likely pathogenic
Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34
Health Risk
RS2519886488
Likely pathogenic
Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34
Health Risk
RS2519886575
Likely pathogenic
Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34
Health Risk
RS2519896045
Likely pathogenic
Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34
Health Risk
All Variants (34)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS751131066 | Health Risk | Conflicting classifications of pathogenicity | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS756534222 | Health Risk | Conflicting classifications of pathogenicity | Syndromic X-linked intellectual disability 34, Intellectual disability, Syndromic X-linked intellectual disability 34 |
| RS759524596 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS2031334549 | Health Risk | Likely pathogenic | Heart, malformation of, Heart |
| RS2031456898 | Health Risk | Likely pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS2031508845 | Health Risk | Likely pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS2148033533 | Health Risk | Likely pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS2148033540 | Health Risk | Likely pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS2148040741 | Health Risk | Likely pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS2519886488 | Health Risk | Likely pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS2519886575 | Health Risk | Likely pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS2519896045 | Health Risk | Likely pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS1057518476 | Health Risk | Pathogenic | — |
| RS1057524408 | Health Risk | Pathogenic | — |
| RS1064796806 | Health Risk | Pathogenic | — |
| RS1085307870 | Health Risk | Pathogenic | — |
| RS1114167441 | Health Risk | Pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS1555949215 | Health Risk | Pathogenic | — |
| RS1555950011 | Health Risk | Pathogenic | Medulloblastoma, Syndromic X-linked intellectual disability 34, Medulloblastoma |
| RS1602385860 | Health Risk | Pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS1602386427 | Health Risk | Pathogenic | — |
| RS1602387702 | Health Risk | Pathogenic | Syndromic X-linked intellectual disability 34, Inborn genetic diseases, Syndromic X-linked intellectual disability 34 |
| RS2031389522 | Health Risk | Pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS2148033408 | Health Risk | Pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS2148033495 | Health Risk | Pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS2148038538 | Health Risk | Pathogenic | Neurodevelopmental delay, Neurodevelopmental delay |
| RS2148039797 | Health Risk | Pathogenic | See cases, See cases |
| RS2519885230 | Health Risk | Pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS2519886525 | Health Risk | Pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS2519886586 | Health Risk | Pathogenic | Non-ossifying fibromas with pathologic factures and X-linked intellectual disability, Non-ossifying fibromas with pathologic factures and X-linked intellectual disability |
| RS869025343 | Health Risk | Pathogenic | Syndromic X-linked intellectual disability 34, Inborn genetic diseases, Syndromic X-linked intellectual disability 34 |
| RS869025344 | Health Risk | Pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS869025345 | Health Risk | Pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |
| RS876661316 | Health Risk | Pathogenic | Syndromic X-linked intellectual disability 34, Syndromic X-linked intellectual disability 34 |