NGF Chromosome 1
Nerve growth factor
Upload your DNA to see your personal genotypes for variants in NGF.
What This Gene Does
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Neurotrophins
Locus Type
gene with protein product
Location
1p13.2
Ensembl
ENSG00000134259
Associated Conditions (4)
Congenital sensory neuropathy with selective loss of small myelinated fibers
Inborn genetic diseases
NGF-related disorder
Peripheral neuropathy
Key Variants
RS1014644520
Conflicting classifications of pathogenicity
Congenital sensory neuropathy with selective loss of small myelinated fibers, Congenital sensory neuropathy with selective loss of small myelinated fibers
Health Risk
RS138175552
Conflicting classifications of pathogenicity
Congenital sensory neuropathy with selective loss of small myelinated fibers, Inborn genetic diseases, Congenital sensory neuropathy with selective loss of small myelinated fibers
Health Risk
RS141486298
Conflicting classifications of pathogenicity
Congenital sensory neuropathy with selective loss of small myelinated fibers, Inborn genetic diseases, Congenital sensory neuropathy with selective loss of small myelinated fibers
Health Risk
RS141889164
Conflicting classifications of pathogenicity
Congenital sensory neuropathy with selective loss of small myelinated fibers, Inborn genetic diseases, Congenital sensory neuropathy with selective loss of small myelinated fibers
Health Risk
RS147326889
Conflicting classifications of pathogenicity
Congenital sensory neuropathy with selective loss of small myelinated fibers, NGF-related disorder, Congenital sensory neuropathy with selective loss of small myelinated fibers
Health Risk
RS149876217
Conflicting classifications of pathogenicity
Congenital sensory neuropathy with selective loss of small myelinated fibers, Congenital sensory neuropathy with selective loss of small myelinated fibers
Health Risk
RS181255687
Conflicting classifications of pathogenicity
Congenital sensory neuropathy with selective loss of small myelinated fibers, Inborn genetic diseases, Congenital sensory neuropathy with selective loss of small myelinated fibers
Health Risk
RS201087374
Conflicting classifications of pathogenicity
Congenital sensory neuropathy with selective loss of small myelinated fibers, Inborn genetic diseases, Congenital sensory neuropathy with selective loss of small myelinated fibers
Health Risk
RS532714783
Conflicting classifications of pathogenicity
Congenital sensory neuropathy with selective loss of small myelinated fibers, Congenital sensory neuropathy with selective loss of small myelinated fibers
Health Risk
RS553442923
Conflicting classifications of pathogenicity
Congenital sensory neuropathy with selective loss of small myelinated fibers, Congenital sensory neuropathy with selective loss of small myelinated fibers
Health Risk
RS770647680
Conflicting classifications of pathogenicity
Congenital sensory neuropathy with selective loss of small myelinated fibers, Inborn genetic diseases, Congenital sensory neuropathy with selective loss of small myelinated fibers
Health Risk
RS886045115
Conflicting classifications of pathogenicity
Congenital sensory neuropathy with selective loss of small myelinated fibers, Congenital sensory neuropathy with selective loss of small myelinated fibers
Health Risk
All Variants (15)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1014644520 | Health Risk | Conflicting classifications of pathogenicity | Congenital sensory neuropathy with selective loss of small myelinated fibers, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS138175552 | Health Risk | Conflicting classifications of pathogenicity | Congenital sensory neuropathy with selective loss of small myelinated fibers, Inborn genetic diseases, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS141486298 | Health Risk | Conflicting classifications of pathogenicity | Congenital sensory neuropathy with selective loss of small myelinated fibers, Inborn genetic diseases, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS141889164 | Health Risk | Conflicting classifications of pathogenicity | Congenital sensory neuropathy with selective loss of small myelinated fibers, Inborn genetic diseases, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS147326889 | Health Risk | Conflicting classifications of pathogenicity | Congenital sensory neuropathy with selective loss of small myelinated fibers, NGF-related disorder, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS149876217 | Health Risk | Conflicting classifications of pathogenicity | Congenital sensory neuropathy with selective loss of small myelinated fibers, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS181255687 | Health Risk | Conflicting classifications of pathogenicity | Congenital sensory neuropathy with selective loss of small myelinated fibers, Inborn genetic diseases, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS201087374 | Health Risk | Conflicting classifications of pathogenicity | Congenital sensory neuropathy with selective loss of small myelinated fibers, Inborn genetic diseases, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS532714783 | Health Risk | Conflicting classifications of pathogenicity | Congenital sensory neuropathy with selective loss of small myelinated fibers, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS553442923 | Health Risk | Conflicting classifications of pathogenicity | Congenital sensory neuropathy with selective loss of small myelinated fibers, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS770647680 | Health Risk | Conflicting classifications of pathogenicity | Congenital sensory neuropathy with selective loss of small myelinated fibers, Inborn genetic diseases, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS886045115 | Health Risk | Conflicting classifications of pathogenicity | Congenital sensory neuropathy with selective loss of small myelinated fibers, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS11466112 | Health Risk | Likely pathogenic | Congenital sensory neuropathy with selective loss of small myelinated fibers, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS2101018240 | Health Risk | Pathogenic | Congenital sensory neuropathy with selective loss of small myelinated fibers, Peripheral neuropathy, Congenital sensory neuropathy with selective loss of small myelinated fibers |
| RS753382007 | Health Risk | Pathogenic | Congenital sensory neuropathy with selective loss of small myelinated fibers, Congenital sensory neuropathy with selective loss of small myelinated fibers |