NEK4 Chromosome 3
NIMA related kinase 4
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What This Gene Does
The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
Gene Info
Gene Group
NIMA related kinase family
Locus Type
gene with protein product
Location
3p21.1
Ensembl
ENSG00000114904
Associated Conditions (1)
Ciliopathy
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS770418305 | Health Risk | Likely pathogenic | Ciliopathy, Ciliopathy |