NDUFB10 Chromosome 16
NADH:ubiquinone oxidoreductase subunit B10
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What This Gene Does
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in nuclear type mitochondrial complex I deficiency 35. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
NADH:ubiquinone oxidoreductase supernumerary subunits
Locus Type
gene with protein product
Location
16p13.3
Ensembl
ENSG00000140990
Associated Conditions (3)
Mitochondrial complex I deficiency
Mitochondrial complex 1 deficiency
nuclear type 35
Key Variants
RS368139423
Conflicting classifications of pathogenicity
Health Risk
RS372530663
Conflicting classifications of pathogenicity
Health Risk
RS1475753965
Likely pathogenic
Mitochondrial complex I deficiency, Mitochondrial complex I deficiency
Health Risk
RS2083254756
Pathogenic
Mitochondrial complex 1 deficiency, nuclear type 35, Mitochondrial complex 1 deficiency
Health Risk
All Variants (4)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS368139423 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS372530663 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1475753965 | Health Risk | Likely pathogenic | Mitochondrial complex I deficiency, Mitochondrial complex I deficiency |
| RS2083254756 | Health Risk | Pathogenic | Mitochondrial complex 1 deficiency, nuclear type 35, Mitochondrial complex 1 deficiency |