NDNF Chromosome 4
Neuron derived neurotrophic factor
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What This Gene Does
Predicted to enable heparin binding activity. Involved in several processes, including cellular response to hypoxia; negative regulation of apoptotic process; and nitric oxide mediated signal transduction. Located in extracellular region. Is active in extracellular space. Implicated in hypogonadotropic hypogonadism. [provided by Alliance of Genome Resources, Jul 2025]
Associated Conditions (1)
Hypogonadotropic hypogonadism 25 with anosmia
Key Variants
RS2476439283
Likely pathogenic
Hypogonadotropic hypogonadism 25 with anosmia, Hypogonadotropic hypogonadism 25 with anosmia
Health Risk
RS1726871489
Pathogenic
Hypogonadotropic hypogonadism 25 with anosmia, Hypogonadotropic hypogonadism 25 with anosmia
Health Risk
RS1726901153
Pathogenic
Hypogonadotropic hypogonadism 25 with anosmia, Hypogonadotropic hypogonadism 25 with anosmia
Health Risk
RS1727077385
Pathogenic
Hypogonadotropic hypogonadism 25 with anosmia, Hypogonadotropic hypogonadism 25 with anosmia
Health Risk
All Variants (4)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2476439283 | Health Risk | Likely pathogenic | Hypogonadotropic hypogonadism 25 with anosmia, Hypogonadotropic hypogonadism 25 with anosmia |
| RS1726871489 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 25 with anosmia, Hypogonadotropic hypogonadism 25 with anosmia |
| RS1726901153 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 25 with anosmia, Hypogonadotropic hypogonadism 25 with anosmia |
| RS1727077385 | Health Risk | Pathogenic | Hypogonadotropic hypogonadism 25 with anosmia, Hypogonadotropic hypogonadism 25 with anosmia |