NCR3 Chromosome 6
Natural cytotoxicity triggering receptor 3
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What This Gene Does
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Gene Info
Gene Group
"CD molecules|V-set domain containing"
Locus Type
gene with protein product
Location
6p21.33
Ensembl
ENSG00000204475
Associated Conditions (4)
Malaria
severe
susceptibility to
mild
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS11575837 | Health Risk | Pathogenic | Malaria, severe, susceptibility to |
| RS2736191 | Health Risk | Pathogenic; risk factor | Malaria, mild, susceptibility to |