NCOR2 Chromosome 12
Nuclear receptor corepressor 2
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What This Gene Does
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Gene Info
Gene Group
"Myb/SANT domain containing|NCoR/SMRT transcriptional repression complex subunits"
Locus Type
gene with protein product
Location
12q24.31
Ensembl
ENSG00000196498
Associated Conditions (1)
Multiple myeloma
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1593107841 | Health Risk | Likely pathogenic | Multiple myeloma, Multiple myeloma |