NAT2 Chromosome 8
N-acetyltransferase 2
Upload your DNA to see your personal genotypes for variants in NAT2.
What This Gene Does
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2). [provided by RefSeq, Sep 2019]
Gene Info
Gene Group
Arylamine N-acetyltransferases
Locus Type
gene with protein product
Location
8p22
Ensembl
ENSG00000156006
Associated Conditions (2)
Slow acetylator due to N-acetyltransferase enzyme variant
NAT2-related disorder
Key Variants
RS1799930
Benign; drug response
Slow acetylator due to N-acetyltransferase enzyme variant, NAT2-related disorder, Slow acetylator due to N-acetyltransferase enzyme variant
Drug Response
RS1801280
Benign; drug response
Slow acetylator due to N-acetyltransferase enzyme variant, NAT2-related disorder, Slow acetylator due to N-acetyltransferase enzyme variant
Drug Response
RS1208
drug response
Slow acetylator due to N-acetyltransferase enzyme variant, Slow acetylator due to N-acetyltransferase enzyme variant
Drug Response
RS1799931
drug response
Slow acetylator due to N-acetyltransferase enzyme variant, Slow acetylator due to N-acetyltransferase enzyme variant
Drug Response
RS1801279
Likely benign; drug response
Slow acetylator due to N-acetyltransferase enzyme variant, NAT2-related disorder, Slow acetylator due to N-acetyltransferase enzyme variant
Drug Response
All Variants (5)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1799930 | Drug Response | Benign; drug response | Slow acetylator due to N-acetyltransferase enzyme variant, NAT2-related disorder, Slow acetylator due to N-acetyltransferase enzyme variant |
| RS1801280 | Drug Response | Benign; drug response | Slow acetylator due to N-acetyltransferase enzyme variant, NAT2-related disorder, Slow acetylator due to N-acetyltransferase enzyme variant |
| RS1208 | Drug Response | drug response | Slow acetylator due to N-acetyltransferase enzyme variant, Slow acetylator due to N-acetyltransferase enzyme variant |
| RS1799931 | Drug Response | drug response | Slow acetylator due to N-acetyltransferase enzyme variant, Slow acetylator due to N-acetyltransferase enzyme variant |
| RS1801279 | Drug Response | Likely benign; drug response | Slow acetylator due to N-acetyltransferase enzyme variant, NAT2-related disorder, Slow acetylator due to N-acetyltransferase enzyme variant |