MT-TF Chromosome MT

Mitochondrially encoded tRNA-Phe (UUU/C)

3 variants 3 Health Risk

Upload your DNA to see your personal genotypes for variants in MT-TF.

What This Gene Does

Predicted to enable triplet codon-amino acid adaptor activity. Predicted to be involved in translation. [provided by Alliance of Genome Resources, Jul 2025]

Gene Info

Gene Group

Mitochondrially encoded transfer RNAs

Locus Type

RNA, transfer

Location

mitochondria

Ensembl

ENSG00000210049

Associated Conditions (10)

MELAS syndrome

Hypokalemia

Hypomagnesemia

Nephropathy

chronic tubulointerstitial

Mitochondrial disease

Epilepsy

mitochondrial

Interstitial nephritis

Primary mitochondrial disorders

Key Variants

RS1603218449

Conflicting classifications of pathogenicity

MELAS syndrome, MELAS syndrome

Health Risk

RS2124590812

Likely pathogenic

Hypokalemia, Hypomagnesemia, Nephropathy

Health Risk

RS387906420

Likely pathogenic

Epilepsy, mitochondrial, MELAS syndrome

Health Risk

All Variants (3)

RSID	Category	Clinical Significance	Conditions
RS1603218449	Health Risk	Conflicting classifications of pathogenicity	MELAS syndrome, MELAS syndrome
RS2124590812	Health Risk	Likely pathogenic	Hypokalemia, Hypomagnesemia, Nephropathy
RS387906420	Health Risk	Likely pathogenic	Epilepsy, mitochondrial, MELAS syndrome