MT-RNR1 Chromosome MT

Mitochondrially encoded 12S rRNA

3 variants 2 Drug Response 1 Health Risk

Upload your DNA to see your personal genotypes for variants in MT-RNR1.

What This Gene Does

Enables DNA binding activity and DNA-binding transcription factor binding activity. Involved in several processes, including osteoblast proliferation; regulation of carbohydrate utilization; and regulation of phosphate metabolic process. Located in extracellular space; mitochondrion; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Gene Info

Gene Group

Mitochondrially encoded ribosomal RNAs

Locus Type

RNA, ribosomal

Location

mitochondria

Ensembl

ENSG00000211459

Associated Conditions (8)

Mitochondrial non-syndromic sensorineural hearing loss

Aminoglycoside-induced deafness

Auditory neuropathy

gentamicin response - Toxicity

aminoglycoside antibacterials response - Toxicity

kanamycin response - Toxicity

streptomycin response - Toxicity

Gentamicin response

Key Variants

RS267606618

drug response

Mitochondrial non-syndromic sensorineural hearing loss, Aminoglycoside-induced deafness, Auditory neuropathy

Drug Response

RS28358569

Uncertain significance; drug response

Mitochondrial non-syndromic sensorineural hearing loss, Aminoglycoside-induced deafness, Gentamicin response

Drug Response

RS1556422499

Pathogenic

Aminoglycoside-induced deafness, Aminoglycoside-induced deafness

Health Risk

All Variants (3)

RSID	Category	Clinical Significance	Conditions
RS267606618	Drug Response	drug response	Mitochondrial non-syndromic sensorineural hearing loss, Aminoglycoside-induced deafness, Auditory neuropathy
RS28358569	Drug Response	Uncertain significance; drug response	Mitochondrial non-syndromic sensorineural hearing loss, Aminoglycoside-induced deafness, Gentamicin response
RS1556422499	Health Risk	Pathogenic	Aminoglycoside-induced deafness, Aminoglycoside-induced deafness