MPO Chromosome 17
Myeloperoxidase
Upload your DNA to see your personal genotypes for variants in MPO.
What This Gene Does
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Gene Info
Gene Group
Heme peroxidase family
Locus Type
gene with protein product
Location
17q22
Ensembl
ENSG00000005381
Associated Conditions (7)
MPO-related disorder
Myeloperoxidase deficiency
Alzheimer disease type 1
Acute myeloid leukemia
Lung cancer
protection against
in smokers
Key Variants
RS149133270
Conflicting classifications of pathogenicity
MPO-related disorder, MPO-related disorder
Health Risk
RS28730837
Conflicting classifications of pathogenicity
Myeloperoxidase deficiency, Myeloperoxidase deficiency
Health Risk
RS778013714
Conflicting classifications of pathogenicity
Myeloperoxidase deficiency, Alzheimer disease type 1, Myeloperoxidase deficiency
Health Risk
RS78950939
Conflicting classifications of pathogenicity
Myeloperoxidase deficiency, Alzheimer disease type 1, Myeloperoxidase deficiency
Health Risk
RS1555607599
Likely pathogenic
Health Risk
RS1970491995
Likely pathogenic
Myeloperoxidase deficiency, Myeloperoxidase deficiency
Health Risk
RS762526880
Likely pathogenic
Myeloperoxidase deficiency, Alzheimer disease type 1, Acute myeloid leukemia
Health Risk
RS762933005
Likely pathogenic
Myeloperoxidase deficiency, Myeloperoxidase deficiency
Health Risk
RS773478778
Likely pathogenic
Myeloperoxidase deficiency, Myeloperoxidase deficiency
Health Risk
RS119469012
Pathogenic
Myeloperoxidase deficiency, Myeloperoxidase deficiency
Health Risk
RS119469013
Pathogenic
Myeloperoxidase deficiency, Myeloperoxidase deficiency
Health Risk
RS181494077
Pathogenic
Myeloperoxidase deficiency, Myeloperoxidase deficiency
Health Risk
All Variants (17)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS149133270 | Health Risk | Conflicting classifications of pathogenicity | MPO-related disorder, MPO-related disorder |
| RS28730837 | Health Risk | Conflicting classifications of pathogenicity | Myeloperoxidase deficiency, Myeloperoxidase deficiency |
| RS778013714 | Health Risk | Conflicting classifications of pathogenicity | Myeloperoxidase deficiency, Alzheimer disease type 1, Myeloperoxidase deficiency |
| RS78950939 | Health Risk | Conflicting classifications of pathogenicity | Myeloperoxidase deficiency, Alzheimer disease type 1, Myeloperoxidase deficiency |
| RS1555607599 | Health Risk | Likely pathogenic | — |
| RS1970491995 | Health Risk | Likely pathogenic | Myeloperoxidase deficiency, Myeloperoxidase deficiency |
| RS762526880 | Health Risk | Likely pathogenic | Myeloperoxidase deficiency, Alzheimer disease type 1, Acute myeloid leukemia |
| RS762933005 | Health Risk | Likely pathogenic | Myeloperoxidase deficiency, Myeloperoxidase deficiency |
| RS773478778 | Health Risk | Likely pathogenic | Myeloperoxidase deficiency, Myeloperoxidase deficiency |
| RS119469012 | Health Risk | Pathogenic | Myeloperoxidase deficiency, Myeloperoxidase deficiency |
| RS119469013 | Health Risk | Pathogenic | Myeloperoxidase deficiency, Myeloperoxidase deficiency |
| RS181494077 | Health Risk | Pathogenic | Myeloperoxidase deficiency, Myeloperoxidase deficiency |
| RS119468010 | Health Risk | Pathogenic/Likely pathogenic | Myeloperoxidase deficiency, Alzheimer disease type 1, MPO-related disorder |
| RS119469014 | Health Risk | Pathogenic/Likely pathogenic | Myeloperoxidase deficiency, MPO-related disorder, Myeloperoxidase deficiency |
| RS536522394 | Health Risk | Pathogenic/Likely pathogenic | Myeloperoxidase deficiency, MPO-related disorder, Myeloperoxidase deficiency |
| RS754632893 | Health Risk | Pathogenic/Likely pathogenic | Myeloperoxidase deficiency, MPO-related disorder, Myeloperoxidase deficiency |
| RS2333227 | Protective | protective; risk factor | Lung cancer, protection against, in smokers |