MOS Chromosome 8
MOS proto-oncogene, serine/threonine kinase
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What This Gene Does
MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]
Associated Conditions (1)
Oocyte/zygote/embryo maturation arrest 20
Key Variants
RS1293467045
Likely pathogenic
Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20
Health Risk
RS1563357810
Pathogenic
Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20
Health Risk
RS2487034928
Pathogenic
Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20
Health Risk
RS2487034940
Pathogenic
Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20
Health Risk
RS2487035279
Pathogenic
Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20
Health Risk
RS2487035768
Pathogenic
Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20
Health Risk
RS2487036131
Pathogenic
Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20
Health Risk
RS774064952
Pathogenic
Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20
Health Risk
All Variants (8)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1293467045 | Health Risk | Likely pathogenic | Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20 |
| RS1563357810 | Health Risk | Pathogenic | Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20 |
| RS2487034928 | Health Risk | Pathogenic | Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20 |
| RS2487034940 | Health Risk | Pathogenic | Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20 |
| RS2487035279 | Health Risk | Pathogenic | Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20 |
| RS2487035768 | Health Risk | Pathogenic | Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20 |
| RS2487036131 | Health Risk | Pathogenic | Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20 |
| RS774064952 | Health Risk | Pathogenic | Oocyte/zygote/embryo maturation arrest 20, Oocyte/zygote/embryo maturation arrest 20 |