MOGS Chromosome 2
Mannosyl-oligosaccharide glucosidase
Upload your DNA to see your personal genotypes for variants in MOGS.
What This Gene Does
This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Info
Gene Group
Glycoside hydrolase family
Locus Type
gene with protein product
Location
2p13.1
Ensembl
ENSG00000115275
Associated Conditions (3)
MOGS-congenital disorder of glycosylation
Inborn genetic diseases
MOGS-related disorder
Key Variants
RS1399649784
Conflicting classifications of pathogenicity
MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation
Health Risk
RS181059661
Conflicting classifications of pathogenicity
MOGS-congenital disorder of glycosylation, Inborn genetic diseases, MOGS-congenital disorder of glycosylation
Health Risk
RS199939051
Conflicting classifications of pathogenicity
MOGS-congenital disorder of glycosylation, MOGS-related disorder, MOGS-congenital disorder of glycosylation
Health Risk
RS202094225
Conflicting classifications of pathogenicity
MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation
Health Risk
RS202102671
Conflicting classifications of pathogenicity
MOGS-congenital disorder of glycosylation, Inborn genetic diseases, MOGS-congenital disorder of glycosylation
Health Risk
RS371747622
Conflicting classifications of pathogenicity
MOGS-congenital disorder of glycosylation, Inborn genetic diseases, MOGS-congenital disorder of glycosylation
Health Risk
RS376424106
Conflicting classifications of pathogenicity
MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation
Health Risk
RS398124221
Conflicting classifications of pathogenicity
MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation
Health Risk
RS745844848
Conflicting classifications of pathogenicity
MOGS-congenital disorder of glycosylation, Inborn genetic diseases, MOGS-congenital disorder of glycosylation
Health Risk
RS757364620
Conflicting classifications of pathogenicity
MOGS-congenital disorder of glycosylation, Inborn genetic diseases, MOGS-congenital disorder of glycosylation
Health Risk
RS764778419
Conflicting classifications of pathogenicity
MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation
Health Risk
RS769741414
Conflicting classifications of pathogenicity
MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation
Health Risk
All Variants (43)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1399649784 | Health Risk | Conflicting classifications of pathogenicity | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS181059661 | Health Risk | Conflicting classifications of pathogenicity | MOGS-congenital disorder of glycosylation, Inborn genetic diseases, MOGS-congenital disorder of glycosylation |
| RS199939051 | Health Risk | Conflicting classifications of pathogenicity | MOGS-congenital disorder of glycosylation, MOGS-related disorder, MOGS-congenital disorder of glycosylation |
| RS202094225 | Health Risk | Conflicting classifications of pathogenicity | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS202102671 | Health Risk | Conflicting classifications of pathogenicity | MOGS-congenital disorder of glycosylation, Inborn genetic diseases, MOGS-congenital disorder of glycosylation |
| RS371747622 | Health Risk | Conflicting classifications of pathogenicity | MOGS-congenital disorder of glycosylation, Inborn genetic diseases, MOGS-congenital disorder of glycosylation |
| RS376424106 | Health Risk | Conflicting classifications of pathogenicity | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS398124221 | Health Risk | Conflicting classifications of pathogenicity | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS745844848 | Health Risk | Conflicting classifications of pathogenicity | MOGS-congenital disorder of glycosylation, Inborn genetic diseases, MOGS-congenital disorder of glycosylation |
| RS757364620 | Health Risk | Conflicting classifications of pathogenicity | MOGS-congenital disorder of glycosylation, Inborn genetic diseases, MOGS-congenital disorder of glycosylation |
| RS764778419 | Health Risk | Conflicting classifications of pathogenicity | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS769741414 | Health Risk | Conflicting classifications of pathogenicity | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS774648411 | Health Risk | Conflicting classifications of pathogenicity | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS1671940053 | Health Risk | Likely pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS2529491095 | Health Risk | Likely pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS2529503594 | Health Risk | Likely pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS2529503989 | Health Risk | Likely pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS747109742 | Health Risk | Likely pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS749858541 | Health Risk | Likely pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS757997140 | Health Risk | Likely pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS776347680 | Health Risk | Likely pathogenic | — |
| RS863225089 | Health Risk | Likely pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS1057520537 | Health Risk | Pathogenic | — |
| RS1199925815 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS121909291 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS121909292 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS1341709717 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS1671936359 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS2529496078 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS2529496158 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS2529496405 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS2529503222 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS2529505867 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS548386762 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS587777323 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS746601093 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS749476593 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS750486813 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS781260708 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS781577192 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS886349456 | Health Risk | Pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |
| RS765427546 | Health Risk | Pathogenic/Likely pathogenic | MOGS-congenital disorder of glycosylation, MOGS-related disorder, MOGS-congenital disorder of glycosylation |
| RS777654978 | Health Risk | Pathogenic/Likely pathogenic | MOGS-congenital disorder of glycosylation, MOGS-congenital disorder of glycosylation |