MNS1 Chromosome 15
Meiosis specific nuclear structural 1
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What This Gene Does
This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]
Associated Conditions (7)
Heterotaxy
visceral
9
autosomal
with male infertility
Situs inversus
MNS1-related disorder
Key Variants
RS139643304
Likely pathogenic
Heterotaxy, visceral, 9
Health Risk
RS1596264554
Likely pathogenic
Situs inversus, Heterotaxy, visceral
Health Risk
RS747360063
Likely pathogenic
MNS1-related disorder, MNS1-related disorder
Health Risk
RS750221808
Likely pathogenic
Heterotaxy, visceral, 9
Health Risk
RS2548617770
Pathogenic
Heterotaxy, visceral, 9
Health Risk
RS549395315
Pathogenic
Heterotaxy, visceral, 9
Health Risk
RS185005213
Pathogenic/Likely pathogenic
Heterotaxy, visceral, 9
Health Risk
All Variants (7)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS139643304 | Health Risk | Likely pathogenic | Heterotaxy, visceral, 9 |
| RS1596264554 | Health Risk | Likely pathogenic | Situs inversus, Heterotaxy, visceral |
| RS747360063 | Health Risk | Likely pathogenic | MNS1-related disorder, MNS1-related disorder |
| RS750221808 | Health Risk | Likely pathogenic | Heterotaxy, visceral, 9 |
| RS2548617770 | Health Risk | Pathogenic | Heterotaxy, visceral, 9 |
| RS549395315 | Health Risk | Pathogenic | Heterotaxy, visceral, 9 |
| RS185005213 | Health Risk | Pathogenic/Likely pathogenic | Heterotaxy, visceral, 9 |