MGST3 Chromosome 1
Microsomal glutathione S-transferase 3
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What This Gene Does
This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
Gene Info
Gene Group
Microsomal glutathione S-transferases
Locus Type
gene with protein product
Location
1q24.1
Ensembl
ENSG00000143198
Associated Conditions (7)
Pulmonary disease
chronic obstructive
susceptibility to
Uveal melanoma
Malignant lymphoma
large B-cell
diffuse
Key Variants
RS11799886
association
Pulmonary disease, chronic obstructive, susceptibility to
Health Risk
RS6681
association
Pulmonary disease, chronic obstructive, susceptibility to
Health Risk
RS8133
association
Pulmonary disease, chronic obstructive, susceptibility to
Health Risk
RS9333378
association
Pulmonary disease, chronic obstructive, susceptibility to
Health Risk
RS957644
association
Pulmonary disease, chronic obstructive, susceptibility to
Health Risk
RS4147611
protective
Pulmonary disease, chronic obstructive, susceptibility to
Protective
All Variants (6)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS11799886 | Health Risk | association | Pulmonary disease, chronic obstructive, susceptibility to |
| RS6681 | Health Risk | association | Pulmonary disease, chronic obstructive, susceptibility to |
| RS8133 | Health Risk | association | Pulmonary disease, chronic obstructive, susceptibility to |
| RS9333378 | Health Risk | association | Pulmonary disease, chronic obstructive, susceptibility to |
| RS957644 | Health Risk | association | Pulmonary disease, chronic obstructive, susceptibility to |
| RS4147611 | Protective | protective | Pulmonary disease, chronic obstructive, susceptibility to |