MEIOB Chromosome 16
Meiosis specific with OB-fold
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What This Gene Does
Predicted to enable chromatin binding activity; single-stranded DNA 3'-5' DNA exonuclease activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; fertilization; and meiotic nuclear division. Located in nucleus. Implicated in primary ovarian insufficiency and spermatogenic failure 22. [provided by Alliance of Genome Resources, Jul 2025]
Associated Conditions (3)
Spermatogenic failure 22
Premature ovarian failure 23
Azoospermia
Key Variants
RS779513355
Likely pathogenic
Spermatogenic failure 22, Premature ovarian failure 23, Spermatogenic failure 22
Health Risk
RS972548876
Likely pathogenic
Health Risk
RS1010446295
Pathogenic
Premature ovarian failure 23, Premature ovarian failure 23
Health Risk
RS1555472691
Pathogenic
Spermatogenic failure 22, Spermatogenic failure 22
Health Risk
RS1899342578
Pathogenic
Spermatogenic failure 22, Spermatogenic failure 22
Health Risk
RS2142076836
Pathogenic
Azoospermia, Azoospermia
Health Risk
RS2548195978
Pathogenic
Spermatogenic failure 22, Spermatogenic failure 22
Health Risk
RS35694423
Pathogenic
Premature ovarian failure 23, Spermatogenic failure 22, Premature ovarian failure 23
Health Risk
RS745502213
Pathogenic
Health Risk
RS750376392
Pathogenic
Spermatogenic failure 22, Premature ovarian failure 23, Spermatogenic failure 22
Health Risk
All Variants (10)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS779513355 | Health Risk | Likely pathogenic | Spermatogenic failure 22, Premature ovarian failure 23, Spermatogenic failure 22 |
| RS972548876 | Health Risk | Likely pathogenic | — |
| RS1010446295 | Health Risk | Pathogenic | Premature ovarian failure 23, Premature ovarian failure 23 |
| RS1555472691 | Health Risk | Pathogenic | Spermatogenic failure 22, Spermatogenic failure 22 |
| RS1899342578 | Health Risk | Pathogenic | Spermatogenic failure 22, Spermatogenic failure 22 |
| RS2142076836 | Health Risk | Pathogenic | Azoospermia, Azoospermia |
| RS2548195978 | Health Risk | Pathogenic | Spermatogenic failure 22, Spermatogenic failure 22 |
| RS35694423 | Health Risk | Pathogenic | Premature ovarian failure 23, Spermatogenic failure 22, Premature ovarian failure 23 |
| RS745502213 | Health Risk | Pathogenic | — |
| RS750376392 | Health Risk | Pathogenic | Spermatogenic failure 22, Premature ovarian failure 23, Spermatogenic failure 22 |